publication

Mora AL, Detalle L, Gallup JM, Van Geelen A, Stohr T, Duprez L, Ackermann MR. Delivery of ALX-0171 by inhalation greatly reduces respiratory syncytial virus disease in newborn lambs. InmAbs 2018 May 2 (No. just-accepted, pp. 1-59). Taylor & Francis.
Roymans D, Alnajjar SS, Battles MB, Sitthicharoenchai P, Furmanova-Hollenstein P, Rigaux P, Van den Berg J, Kwanten L, Van Ginderen M, Verheyen N, Vranckx L. Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor. Nature communications. 2017 Aug 1;8(1):167.
Mora AL, Detalle L, Van Geelen A, Davis MS, Stohr T, Gallup JM, Ackermann MR. Kinetics of respiratory syncytial virus (RSV) Memphis strain 37 (M37) infection in the respiratory tract of newborn lambs as an RSV infection model for human infants. PloS one. 2015 Dec 7;10(12):e0143580.
Ackermann MR. Lamb model of respiratory syncytial virus–associated lung disease: insights to pathogenesis and novel treatments. ILAR journal. 2014 Jan 1;55(1):4-15.
Derscheid RJ, van Geelen A, Gallup JM, Kienzle T, Shelly DA, Cihlar T, King RR, Ackermann MR. Human respiratory syncytial virus memphis 37 causes acute respiratory disease in perinatal lamb lung. BioResearch open access. 2014 Apr 1;3(2):60-9.
Grosz DD, van Geelen A, Gallup JM, Hostetter SJ, Derscheid RJ, Ackermann MR. Sucrose stabilization of Respiratory Syncytial Virus (RSV) during nebulization and experimental infection. BMC research notes. 2014 Dec;7(1):158.
Derscheid RJ, van Geelen A, Berkebile AR, Gallup JM, Hostetter SJ, Banfi B, McCray Jr PB, Ackermann MR. Increased concentration of iodide in airway secretions is associated with reduced respiratory syncytial virus disease severity. American journal of respiratory cell and molecular biology. 2014 Feb;50(2):389-97.
Derscheid RJ, Gallup JM, Knudson CJ, Varga SM, Grosz DD, van Geelen A, Hostetter SJ, Ackermann MR. Effects of formalin-inactivated respiratory syncytial virus (FI-RSV) in the perinatal lamb model of RSV. PloS one. 2013 Dec 6;8(12):e81472.
Derscheid RJ, van Geelen A, McGill JL, Gallup JM, Cihlar T, Sacco RE, Ackermann MR. Human respiratory syncytial virus Memphis 37 grown in HEp-2 cells causes more severe disease in lambs than virus grown in Vero cells. Viruses. 2013 Nov 22;5(11):2881-97.
Derscheid RJ, Ackermann MR. The innate immune system of the perinatal lung and responses to respiratory syncytial virus infection. Veterinary pathology. 2013 Sep;50(5):827-41.
Sow FB, Gallup JM, Derscheid R, Krishnan S, Ackermann MR. Ontogeny of the immune response in the ovine lung. Immunological investigations. 2012 Apr 1;41(3):304-16.
Derscheid RJ, Ackermann MR. Perinatal lamb model of respiratory syncytial virus (RSV) infection. Viruses. 2012 Oct 23;4(10):2359-78.
Olivier AK, Gallup JM, Geelen AV, Ackermann MR. Exogenous administration of vascular endothelial growth factor prior to human respiratory syncytial virus a2 infection reduces pulmonary pathology in neonatal lambs and alters epithelial innate immune responses. Experimental lung research. 2011 Mar 18;37(3):131-43.
Sow FB, Gallup JM, Krishnan S, Patera AC, Suzich J, Ackermann MR. Respiratory syncytial virus infection is associated with an altered innate immunity and a heightened pro-inflammatory response in the lungs of preterm lambs. Respiratory research. 2011 Dec;12(1):106.
Lazic T, Sow FB, Van Geelen A, Meyerholz DK, Gallup JM, Ackermann MR. Exposure to ethanol during the last trimester of pregnancy alters the maturation and immunity of the fetal lung. Alcohol. 2011 Nov 1;45(7):673-80.
Sow FB, Gallup JM, Olivier A, Krishnan S, Patera AC, Suzich J, Ackermann MR. Respiratory syncytial virus is associated with an inflammatory response in lungs and architectural remodeling of lung-draining lymph nodes of newborn lambs. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2010 Oct 8;300(1):L12-24.
Lazic T, Matic M, Gallup JM, Van Geelen A, Meyerholz DK, Grubor B, Imerman PM, de‐Macedo MM, Ackermann MR. Effects of nicotine on pulmonary surfactant proteins A and D in ovine lung epithelia. Pediatric pulmonology. 2010 Mar;45(3):255-62.
Radi ZA, Meyerholz DK, Ackermann MR. Pulmonary cyclooxygenase-1 (COX-1) and COX-2 cellular expression and distribution after respiratory syncytial virus and parainfluenza virus infection. Viral immunology. 2010 Feb 1;23(1):43-8.
Radi ZA, Ackermann MR. Ontogeny of pulmonary cyclooxygenase-1 (COX-1) and-2 (COX-2). Pathophysiology. 2011 Jun 1;18(3):215-9.
Olivier A, Gallup J, De Macedo MM, Varga SM, Ackermann M. Human respiratory syncytial virus A2 strain replicates and induces innate immune responses by respiratory epithelia of neonatal lambs. International journal of experimental pathology. 2009 Aug;90(4):431-8.
Sow FB, Gallup JM, Meyerholz DK, Ackermann MR. Gene profiling studies in the neonatal ovine lung show enhancing effects of VEGF on the immune response. Developmental & Comparative Immunology. 2009 Jun 1;33(6):761-71.
Meyerholz DK, Gallup JM, Lazic T, De Macedo MM, Lehmkuhl HD, Ackermann MR. Pretreatment with recombinant human vascular endothelial growth factor reduces virus replication and inflammation in a perinatal lamb model of respiratory syncytial virus infection. Viral immunology. 2007 Mar 1;20(1):188-96.
Lazic T, Wyatt TA, Matic M, Meyerholz DK, Grubor B, Gallup JM, Kersting KW, Imerman PM, Almeida-De-Macedo M, Ackermann MR. Maternal alcohol ingestion reduces surfactant protein A expression by preterm fetal lung epithelia. Alcohol. 2007 Aug 1;41(5):347-55.
Fach SJ, Meyerholz DK, Gallup JM, Ackermann MR, Lehmkuhl HD, Sacco RE. Neonatal ovine pulmonary dendritic cells support bovine respiratory syncytial virus replication with enhanced interleukin (IL)-4 And IL-10 gene transcripts. Viral immunology. 2007 Mar 1;20(1):119-30.
Kawashima K, Meyerholz DK, Gallup JM, Grubor B, Lazic T, Lehmkuhl HD, Ackermann MR. Differential expression of ovine innate immune genes by preterm and neonatal lung epithelia infected with respiratory syncytial virus. Viral immunology. 2006 Jun 1;19(2):316-23.
Meyerholz DK, Kawashima K, Gallup JM, Grubor B, Ackermann MR. Expression of select immune genes (surfactant proteins A and D, sheep beta defensin 1, and toll-like receptor 4) by respiratory epithelia is developmentally regulated in the preterm neonatal lamb. Developmental & Comparative Immunology. 2006 Jan 1;30(11):1060-9.
Meyerholz DK, Grubor B, Lazic T, Gallup JM, De Macedo MM, McCray Jr PB, Ackermann MR. Monocytic/macrophagic pneumonitis after intrabronchial deposition of vascular endothelial growth factor in neonatal lambs. Veterinary pathology. 2006 Sep;43(5):689-94.
Meyerholz DK, DeGraaf JA, Gallup JM, Olivier AK, Ackermann MR. Depletion of alveolar glycogen corresponds with immunohistochemical development of CD208 antigen expression in perinatal lamb lung. Journal of Histochemistry & Cytochemistry. 2006 Nov;54(11):1247-53.
Meyerholz DK, Grubor B, Fach SJ, Sacco RE, Lehmkuhl HD, Gallup JM, Ackermann MR. Reduced clearance of respiratory syncytial virus infection in a preterm lamb model. Microbes and infection. 2004 Nov 1;6(14):1312-9.
Grubor B, Gallup JM, Meyerholz DK, Crouch EC, Evans RB, Brogden KA, Lehmkuhl HD, Ackermann MR. Enhanced surfactant protein and defensin mRNA levels and reduced viral replication during parainfluenza virus type 3 pneumonia in neonatal lambs. Clinical and diagnostic laboratory immunology. 2004 May 1;11(3):599-607.
Meyerholz DK, Grubor B, Gallup JM, Lehmkuhl HD, Anderson RD, Lazic T, Ackermann MR. Adenovirus-mediated gene therapy enhances parainfluenza virus 3 infection in neonatal lambs. Journal of clinical microbiology. 2004 Oct 1;42(10):4780-7.
Brogden KA, Kalfa VC, Ackermann MR, Palmquist DE, McCray PB, Tack BF. The ovine cathelicidin SMAP29 kills ovine respiratory pathogens in vitro and in an ovine model of pulmonary infection. Antimicrobial agents and chemotherapy. 2001 Jan 1;45(1):331-4.
Kalfa VC, Palmquist D, Ackermann MR, Brogden KA. Suppression of Mannheimia (Pasteurella) haemolytica serovar 1 infection in lambs by intrapulmonary administration of ovine antimicrobial anionic peptide. International journal of antimicrobial agents. 2001 Jun 1;17(6):505-10.

Mora AL, Detalle L, Gallup JM, Van Geelen A, Stohr T, Duprez L, Ackermann MR. Delivery of ALX-0171 by inhalation greatly reduces respiratory syncytial virus disease in newborn lambs. InmAbs 2018 May 2 (No. just-accepted, pp. 1-59). Taylor & Francis.

Roymans D, Alnajjar SS, Battles MB, Sitthicharoenchai P, Furmanova-Hollenstein P, Rigaux P, Van den Berg J, Kwanten L, Van Ginderen M, Verheyen N, Vranckx L. Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor. Nature communications. 2017 Aug 1;8(1):167.

Mora AL, Detalle L, Van Geelen A, Davis MS, Stohr T, Gallup JM, Ackermann MR. Kinetics of respiratory syncytial virus (RSV) Memphis strain 37 (M37) infection in the respiratory tract of newborn lambs as an RSV infection model for human infants. PloS one. 2015 Dec 7;10(12):e0143580.

Ackermann MR. Lamb model of respiratory syncytial virus–associated lung disease: insights to pathogenesis and novel treatments. ILAR journal. 2014 Jan 1;55(1):4-15.

Derscheid RJ, van Geelen A, Gallup JM, Kienzle T, Shelly DA, Cihlar T, King RR, Ackermann MR. Human respiratory syncytial virus memphis 37 causes acute respiratory disease in perinatal lamb lung. BioResearch open access. 2014 Apr 1;3(2):60-9.

Grosz DD, van Geelen A, Gallup JM, Hostetter SJ, Derscheid RJ, Ackermann MR. Sucrose stabilization of Respiratory Syncytial Virus (RSV) during nebulization and experimental infection. BMC research notes. 2014 Dec;7(1):158.

Derscheid RJ, Gallup JM, Knudson CJ, Varga SM, Grosz DD, van Geelen A, Hostetter SJ, Ackermann MR. Effects of formalin-inactivated respiratory syncytial virus (FI-RSV) in the perinatal lamb model of RSV. PloS one. 2013 Dec 6;8(12):e81472.

Derscheid RJ, van Geelen A, McGill JL, Gallup JM, Cihlar T, Sacco RE, Ackermann MR. Human respiratory syncytial virus Memphis 37 grown in HEp-2 cells causes more severe disease in lambs than virus grown in Vero cells. Viruses. 2013 Nov 22;5(11):2881-97.

Derscheid RJ, Ackermann MR. The innate immune system of the perinatal lung and responses to respiratory syncytial virus infection. Veterinary pathology. 2013 Sep;50(5):827-41.

Sow FB, Gallup JM, Derscheid R, Krishnan S, Ackermann MR. Ontogeny of the immune response in the ovine lung. Immunological investigations. 2012 Apr 1;41(3):304-16.

Derscheid RJ, Ackermann MR. Perinatal lamb model of respiratory syncytial virus (RSV) infection. Viruses. 2012 Oct 23;4(10):2359-78.

Sow FB, Gallup JM, Krishnan S, Patera AC, Suzich J, Ackermann MR. Respiratory syncytial virus infection is associated with an altered innate immunity and a heightened pro-inflammatory response in the lungs of preterm lambs. Respiratory research. 2011 Dec;12(1):106.

Lazic T, Sow FB, Van Geelen A, Meyerholz DK, Gallup JM, Ackermann MR. Exposure to ethanol during the last trimester of pregnancy alters the maturation and immunity of the fetal lung. Alcohol. 2011 Nov 1;45(7):673-80.

Lazic T, Matic M, Gallup JM, Van Geelen A, Meyerholz DK, Grubor B, Imerman PM, de‐Macedo MM, Ackermann MR. Effects of nicotine on pulmonary surfactant proteins A and D in ovine lung epithelia. Pediatric pulmonology. 2010 Mar;45(3):255-62.

Radi ZA, Meyerholz DK, Ackermann MR. Pulmonary cyclooxygenase-1 (COX-1) and COX-2 cellular expression and distribution after respiratory syncytial virus and parainfluenza virus infection. Viral immunology. 2010 Feb 1;23(1):43-8.

Radi ZA, Ackermann MR. Ontogeny of pulmonary cyclooxygenase-1 (COX-1) and-2 (COX-2). Pathophysiology. 2011 Jun 1;18(3):215-9.

Olivier A, Gallup J, De Macedo MM, Varga SM, Ackermann M. Human respiratory syncytial virus A2 strain replicates and induces innate immune responses by respiratory epithelia of neonatal lambs. International journal of experimental pathology. 2009 Aug;90(4):431-8.

Sow FB, Gallup JM, Meyerholz DK, Ackermann MR. Gene profiling studies in the neonatal ovine lung show enhancing effects of VEGF on the immune response. Developmental & Comparative Immunology. 2009 Jun 1;33(6):761-71.

Meyerholz DK, Gallup JM, Lazic T, De Macedo MM, Lehmkuhl HD, Ackermann MR. Pretreatment with recombinant human vascular endothelial growth factor reduces virus replication and inflammation in a perinatal lamb model of respiratory syncytial virus infection. Viral immunology. 2007 Mar 1;20(1):188-96.

Lazic T, Wyatt TA, Matic M, Meyerholz DK, Grubor B, Gallup JM, Kersting KW, Imerman PM, Almeida-De-Macedo M, Ackermann MR. Maternal alcohol ingestion reduces surfactant protein A expression by preterm fetal lung epithelia. Alcohol. 2007 Aug 1;41(5):347-55.

Fach SJ, Meyerholz DK, Gallup JM, Ackermann MR, Lehmkuhl HD, Sacco RE. Neonatal ovine pulmonary dendritic cells support bovine respiratory syncytial virus replication with enhanced interleukin (IL)-4 And IL-10 gene transcripts. Viral immunology. 2007 Mar 1;20(1):119-30.

Kawashima K, Meyerholz DK, Gallup JM, Grubor B, Lazic T, Lehmkuhl HD, Ackermann MR. Differential expression of ovine innate immune genes by preterm and neonatal lung epithelia infected with respiratory syncytial virus. Viral immunology. 2006 Jun 1;19(2):316-23.

Meyerholz DK, Grubor B, Lazic T, Gallup JM, De Macedo MM, McCray Jr PB, Ackermann MR. Monocytic/macrophagic pneumonitis after intrabronchial deposition of vascular endothelial growth factor in neonatal lambs. Veterinary pathology. 2006 Sep;43(5):689-94.

Meyerholz DK, DeGraaf JA, Gallup JM, Olivier AK, Ackermann MR. Depletion of alveolar glycogen corresponds with immunohistochemical development of CD208 antigen expression in perinatal lamb lung. Journal of Histochemistry & Cytochemistry. 2006 Nov;54(11):1247-53.

Meyerholz DK, Grubor B, Fach SJ, Sacco RE, Lehmkuhl HD, Gallup JM, Ackermann MR. Reduced clearance of respiratory syncytial virus infection in a preterm lamb model. Microbes and infection. 2004 Nov 1;6(14):1312-9.

Meyerholz DK, Grubor B, Gallup JM, Lehmkuhl HD, Anderson RD, Lazic T, Ackermann MR. Adenovirus-mediated gene therapy enhances parainfluenza virus 3 infection in neonatal lambs. Journal of clinical microbiology. 2004 Oct 1;42(10):4780-7.

Brogden KA, Kalfa VC, Ackermann MR, Palmquist DE, McCray PB, Tack BF. The ovine cathelicidin SMAP29 kills ovine respiratory pathogens in vitro and in an ovine model of pulmonary infection. Antimicrobial agents and chemotherapy. 2001 Jan 1;45(1):331-4.

Kalfa VC, Palmquist D, Ackermann MR, Brogden KA. Suppression of Mannheimia (Pasteurella) haemolytica serovar 1 infection in lambs by intrapulmonary administration of ovine antimicrobial anionic peptide. International journal of antimicrobial agents. 2001 Jun 1;17(6):505-10.